Recently, in a research report published in international magazine PNAS, scientists from institutions such as Case Western Reserve University School of Medicine revealed that during the occurrence of schizophrenia, a special name called neuregulin 3 was discovered. Proteins regulate the molecular mechanisms of the release of key neurotransmitters in the brain. Neuregulin-3 has a higher level in the body of patients with schizophrenia and other severe mental disorders. In this study, the researchers first elucidated how neuregulin 3 triggers Severe mental illness.
In the article, researchers unveiled the function of neuregulin 3 using advanced technologies. They found that the protein can inhibit the function of protein complexes required for proper neuronal communication; specific mutations encoding the neuregulin 3 gene are thought to be In direct correlation with individuals suffering from schizophrenia, the researchers explained why neuregulin 3 is so important to the disease; Dr. Lin Mei said that we identified a novel function of schizophrenia susceptibility gene, neuregulin-3. This may provide us with new clues and ideas for understanding the cytological mechanisms of various mental disorders and developing new targeted therapies. By understanding the role of neuregulin 3 in the brain, we can design new drugs to restore The function of the protein in the body of the patient when schizophrenia occurs.
Schizophrenia affects approximately 1 in 100 adults in the United States, and its pathogenesis is difficult to understand. It is difficult for researchers to identify many of the associated proteins and neurotransmitters that appear behind the disease. In this study, Researchers have discovered a unique mechanism in neurons that has never been seen before because of schizophrenia. In the article, the researchers mutated the gene encoding neuregulin 3 in mouse bodies (but only in special neuronal cells) when they mutated the neuregulin 3 gene in pyramidal neurons that activate brain activity. At the time, genetically modified mice exhibit behavior consistent with schizophrenia. These mice still have healthy physical and body reflexes, but they are extremely active. They are difficult to remember and difficult to find in mazes. Navigation; In social relationships, mice stay away from strangers. This study not only sheds light on the key role of neuregulin 3 in schizophrenia, but also helps to define effectively the type of neurons involved in the entire process. .
By studying brain samples from mice, the researchers elucidated the mechanism of action of neuregulin 3 at the cellular level. They found that neuregulin 3 can inhibit the assembly of synaptic site protein complexes, and this position is adjacent to At the site of nerve cell communication, neurons need a complex called SNARE to transfer special neurotransmitters between neuronal cells. In particular, the SNARE complex can help neurons deliver glutamate, and glutamate can help. Activation of neurons is very important for the body's learning function, and the imbalance of glutamate can cause symptoms such as schizophrenia in the body.
Patients with multiple mental disorders are usually more likely to have high levels of neuregulin 3 in the body, such as schizophrenia, bipolar disorder, and severe depression; researchers increase levels of neuregulin 3 in cultured neurons. Simulating the level of this protein in the brain of schizophrenia patients, they found that high levels of neuregulin 3 can inhibit the release of glutamate, while cells carrying high levels of neuregulin 3 do not form SNARE complexes. Excessive inhibitory proteins often inhibit the formation of complexes while also inhibiting glutamate levels in brain cells. The investigators conclude that neuregulin 3 is important for proper glutamate delivery in the brain.
Researcher Mei said that we found that neuregulin 3 functions more efficiently than other proteins in the family, such as neuregulin 1 that activates a completely different set of proteins in other types of neurons; In cancer biology research, neuregulin 3 can stimulate the expression of ErbB4, another risk gene for schizophrenia. Surprisingly, the researchers found that neuregulin 3 in the brain may not work by activating ErbB4. On the contrary, it can regulate the release of glutamate, and this new function does not require the participation of ErbB4.
This study shows that neuregulin 3 may serve as a novel therapeutic target to help researchers develop new therapies for various mental disorders such as schizophrenia. Targeted drugs that target neuregulin 3 can help restore specific The level of glutamate in neuronal cells, which can be used as a new type of schizophrenia therapy, to identify a new mechanism of action is to understand the preconditions for the occurrence of the disease, but also for the later development of disease treatment for scientists New therapies provide some research basis and clues.
Kojic acid is an organic compound with molecular formula of c6h6o4 and molecular weight of 142.11. Colorless prismatic crystal. It is used as Antioxidant and anti radiation agent. It is used in the field of cosmetics. In human skin, tyrosine is catalysed by tyrosinase, and then oxidized and polymerized with oxygen free radical to synthesize melanin. Kojic acid can inhibit tyrosinase synthesis, so it can strongly inhibit the formation of skin melanin, and is safe and non-toxic, and does not produce leukoplakia sequela. Kojic acid has been incorporated into make-up water, facial mask, emulsion and skin cream. It can be used to treat freckles, senile plaques, pigmentation, acne and other high-grade whitening cosmetics effectively.
Product Name: Kojic Acid Dipalmitate Powder
Appearance : White Powder
Specification: 99%
CAS: 79725-98-7
MOLECULAR FORMULA: C38O6H66
MOLECULAR WEIGHT: 618.91
SYNONYMS : 2-Palmitoyloxymethyl-5-palmitoyloxy-pyrone;2-Palmitoyloxymethyl-5-palmitoyloxy-gamma-pyrone;
Kojic acid dipalmitate is a derivative of Kojic Acid and palmitic acid, which not only overcomes the instability to light, heat and metallic ion, but keeps the inhibitory tyrosinase activity and prevents the forming of melanin. It is easier to be absorbed by the skin. IMAHERB BIOTECH is one of the professional and credible top quality GMP Manufacture ISO Certified Kojic Acid Dipalmitate Cosmetic Raw Material 99% for sale manufacturers, who is dedicated to produce the top quality organic products which is of great benefits to customers. If you want to know how to buy such products, welcome to contact us and we will offer you the best price.
Skin care, sun care, skin whitening/lightening, treatment for pigmentary disorders such as age spots etc.Function:Kojic dipalmitate owns stable chemical property. It will not turn yellow for oxidation, metallic ion, illumination and heating. As fat soluble skin whitening agent,it is easier to be absorbed by skin.With the most advanced technology, kojic dipalmitate synthesized by our company has the most shallow color and the minimum impurity.
Why choose us?
Product Recommended
Alpha Arbutin, Cosmetic Grade Product, is mainly extracted from the leaves of bearberry. α- Arbutin can also be found in some fruits and other plants. It has the effect of brightening the skin. It can be used in high-grade cosmetics, such as skin care cream, freckle cream, high-grade pearl cream, etc. it can not only make skin care, but also reduce inflammation and anti irritation. Ellagic acid, it has many bioactive functions, such as antioxidant, anticancer, antimutagenic and anti HIV. In addition, ellagic acid is also an effective coagulant, which has a good inhibitory effect on a variety of bacteria and viruses. It can protect the wound from the invasion of bacteria, prevent infection and inhibit ulcer. At the same time, ellagic acid also has antihypertensive and sedative effects. Glycyrrhizic acid, an organic compound, can be used as Sweetener, flavoring agent and flavor enhancer. Using in skin care products can enhance the efficacy of other active substances in sunscreen, whitening, antipruritic, conditioning and scar healing. Sepiwhite Msh Powder is a kind of melanin stimulating hormone( α- MSH receptor antagonist, mainly used in cosmetics as a whitening agent.
Kojic Acid,Kojic Acid Dipalmitate,Tranexamic Acid,Sepiwhite Msh Powder
Xi'an Tian Guangyuan Biotech Co., Ltd. , https://www.tgybiotech.com