Experience the experience of genetic testing: database information errors can be a nightmare for precision medicine

When you are involved in genetic testing, how do you get valuable data, and how does genetic analysis relate to certain functions? The well-known American journalist REBECCA ROBBINS has experienced genetic testing services from DNAFit, Genomic Express, Kinetic Diagnostics, Orig3n, and Simplified Genetics. The price ranges from $154 to $400, which helps us have a preliminary understanding of the industry.

My genes determine that I am more suitable for high-intensity aerobic exercise than low-intensity aerobic exercise. In fact, I am not sure, because I have made two genetic tests on the mail, and they have given two completely different explanations for the chromosomes in the same position in my DNA.

Maybe I should take a third test. Maybe the same genotype will be interpreted as, I have benefited from the fried chicken egg white, quinoa salad and fried chicken that I have eaten on Sunday.

Experience the experience of genetic testing: database information errors can be a nightmare for precision medicine

After completing the five most popular genetic tests for athletes, I found myself in this mirrored hall. The athletes here include both high-level competitors and joggers like me for entertainment purposes. . The test promises to analyze my genetic components, provide "unprecedented insights" about my "bodybuilding potential", or help my body achieve optimal results.

But some tests are flat and contradictory. For the risk of my tendon strain, these tests suggest that the genome of a particular region causes these risks and gives a different interpretation. For example, I am prone to high blood pressure, and the corresponding genomic group has caused me to get high blood pressure.

I accept such a test, I really hope that the test can help me explain why I am good at a certain type of exercise. (I wanted to be a softball pitcher in the high school age.) I also hoped that they would provide useful tips to improve my current motor skills.

Since receiving the test, I have endured them taking seven bottles of blood from my arm at once. Inadvertently caused bleeding inside the cheeks. I also stumbled upon the chance of suffering from Alzheimer's disease, but I didn't want to know about this fact. But what about that? Did not get anything of value.

Genetic analysis companies are building alliances with personal trainers, chiropractors and instructors around the world to promote genome testing, which they believe can help athletes at all levels to tailor their training to their DNA. They have worked with the Baylor University football team in Texas, the British Premier League, the Egyptian football team, Arizona's elite training facilities, top track and field athletes, and many of them have participated in the Rio Olympics. Player.

However, there is no scientific basis to support the notion that genetic analysis can identify whether a particular athlete tends to benefit from certain types of exercise, is prone to tendon injury, or recovers from difficult exercise.

According to a consensus statement published last year in the British Journal of Sports Medicine, these tests “have no effect in talent identification or personalized training programs, and thus have no meaning for them to achieve the highest level through appropriate training”, this statement Signed by more than 20 experts in genomics and athletic performance.

As far as I know, there are few studies on how to interpret the relationship between genes and personal fitness levels. And there is actually no evidence to show how athletes should take appropriate countermeasures against the information they receive.

This may also be why the information I get is generally frustrating for me, and they give general common sense advice, such as stretching the body before exercise. There are some details that are weird (not entirely impossible for me), such as a menu that tells me to eat quinoa on Sunday.

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