Tangential Flow Filtration (TFF) Frequently Asked Questions and Answers 1. How to determine the cleaning effect of ultrafiltration membrane?
Many users encounter cleaning problems with ultrafiltration membranes. What is the method for determining the cleanliness of ultrafiltration membranes? Is the standard water flux, referred to as: NWP, the unit is: liter / square meter / hour / bar, that is, the unit membrane area, the flow of water through the membrane under unit pressure:
NWP = water flow X temperature correction factor / TMP / membrane area where membrane penetration pressure TMP = (Pin + Pout) / 2 - Pp, the average of the inlet pressure plus outlet pressure minus the filtration fluid pressure. NWP is not an indicator, but it can be used as an important indicator to measure the permeability of the membrane after cleaning the ultrafiltration membrane. The figure below shows the variation of NWP with the number of uses, and the green curve is good. If the blue or gray curve is the case in your application, then a review of the cleaning study or process conditions is necessary, and Millipore can provide the corresponding (message or Millipore Ultrafiltration).
2. How long does it take for the ultrafiltration membrane pack, or how long does it take to replace the ultrafiltration membrane pack?
This is a very good problem, and it is also a very big problem. It is usually replaced under the following conditions: the flow rate is very low, the ultrafiltration time is too long, the product is leaked, and the integrity test is unqualified. 3. How often do you perform an integrity test for ultrafiltration membranes? (1) There are no clear rules;
(2) may be in accordance with the provisions of the SOP;
(3) When you suspect that there is a problem;
(4) When you encounter a product in the filtrate;
(5) If an integrity test is allowed after each cleaning process.
Many users encounter cleaning problems with ultrafiltration membranes. What is the method for determining the cleanliness of ultrafiltration membranes? Is the standard water flux, referred to as: NWP, the unit is: liter / square meter / hour / bar, that is, the unit membrane area, the flow of water through the membrane under unit pressure:
NWP = water flow X temperature correction factor / TMP / membrane area where membrane penetration pressure TMP = (Pin + Pout) / 2 - Pp, the average of the inlet pressure plus outlet pressure minus the filtration fluid pressure. NWP is not an indicator, but it can be used as an important indicator to measure the permeability of the membrane after cleaning the ultrafiltration membrane. The figure below shows the variation of NWP with the number of uses, and the green curve is good. If the blue or gray curve is the case in your application, then a review of the cleaning study or process conditions is necessary, and Millipore can provide the corresponding (message or Millipore Ultrafiltration).
2. How long does it take for the ultrafiltration membrane pack, or how long does it take to replace the ultrafiltration membrane pack?
This is a very good problem, and it is also a very big problem. It is usually replaced under the following conditions: the flow rate is very low, the ultrafiltration time is too long, the product is leaked, and the integrity test is unqualified. 3. How often do you perform an integrity test for ultrafiltration membranes? (1) There are no clear rules;
(2) may be in accordance with the provisions of the SOP;
(3) When you suspect that there is a problem;
(4) When you encounter a product in the filtrate;
(5) If an integrity test is allowed after each cleaning process.
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