In the experiment, the researchers first transplanted the tumor subcutaneously to the lateral abdomen on both sides of the test mouse, and then injected the complex into the bilateral flanks after 7 days. In the next 10 days, the researchers irradiated the tumor site with a red semiconductor laser with a wavelength of 670 nm for 15 minutes each day. After 10 days, the tumor disappeared. A few days after stopping the laser irradiation, the tumor did not recur. If the injection is not a complex, but a single zinc phthalocyanine or carbon nanohorn, and then laser irradiation, it can also play a certain role in combating tumors, but the tumor will not disappear.
The researchers believe that the use of carbon nanohorns to carry zinc phthalocyanine enables the photosensitizer to be efficiently concentrated in the affected part of the tumor, and the use of laser irradiation to produce reactive oxygen species of zinc phthalocyanine can achieve significant photodynamic effects. The carbon nanohorn itself also heats up by absorbing light, killing surrounding cancer cells. Therefore, the complex of the three can obtain the multiplier effect of photodynamic therapy and photothermal therapy. The communique said that researchers have determined that carbon nanohorns have very low-term toxicity to the body. They plan to observe their long-term toxicity and try to get carbon nanohorns out of the body after treatment.
Humans have discovered tumors for more than 3,000 years. Not only do humans have tumors, but also animals and plants. It was not until the application of the microscope in the 19th century that the current framework of oncology was established. Since the 20th century, due to the development of natural science, basic theoretical research and the application of new technologies, oncology research has made great progress. Although malignant tumors have become the first or second cause of death in humans, advances in oncology have made 1/3 of cancer patients have a cure.
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