Significant progress in the early diagnosis and diagnosis of contrast agents in tumors

Release date: 2006-12-14

Significant progress in the early diagnosis and diagnosis of contrast agents for tumors Recently, the research group of the researcher Gao Mingyuan, key laboratory of the Institute of Colloid, Interface and Chemical Thermal Power, Institute of Chemistry, Chinese Academy of Sciences, used the early differential diagnosis of small tumors as the entry point, and carried out the surface with functions. Preparation of biocompatible magnetic nanocrystals of groups and their application in early detection of tumors. Based on solid preliminary work, they use the "one-pot" reaction preparation technology of biocompatible magnetic nanocrystals with independent intellectual property rights. By using dicarboxy PEG as a stabilizer, they successfully use one-step reaction to prepare the surface. A biocompatible magnetic nanocrystal of a carboxyl group. The coupling obtained by covalently coupling the carboxyl group on the surface of the magnetic nanocrystal with the anti-tumor antibody in the living body of the animal shows obvious tumor targeting function and magnetic resonance imaging function for assisting differential diagnosis of small tumor.
The results of this experiment show that the new synthetic technology established by the research group has matured, and the magnetic nanocrystals prepared by the technology are expected to be used in the diagnosis of diseases. Magnetic nanoparticles have broad application prospects in the biomedical field, including biological separation, magnetic resonance imaging, magnetic targeting drugs, and magnetothermal treatment of tumors.
However, up to now, the application of magnetic nanomaterials in the field of biomedicine, especially in vivo applications, is at the bottleneck. In vivo applications, as the ultimate goal of magnetic nanomaterials in the medical field, require magnetic nanomaterials not only to have good water solubility and biocompatibility, but also to have surface functionality. The coupling of surface functional groups of magnetic nanomaterials with functional (large) molecules that can recognize lesions is one of the most feasible means to realize the application of magnetic nanocrystals in differential diagnosis of diseases.
—— Information from: China Medical Information Network

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