Chinese Pinyin fu fang gan mao ling ke li
English name Fu fang gan mao ling granules
Medication classification medical medicine
Role category
The drug consists of 104g of honeysuckle, 415g of Wuzhigan, 310g of wild chrysanthemum, 520g of trigeminal, 310g of southern blue root, 835g of Gangmei, 16.8g of acetaminophen, 0.268g of chlorpheniramine maleate, and 1.2g of caffeine.
Characters This product is brown to dark brown granules or block granules; sweet and slightly bitter.
The effect of Xin Liang Jie table, heat and detoxification.
Indications of fever, fever and fever, mild and cold, head and body pain, dry mouth and thirst, nasal congestion, phlegm, throat swelling, pain, cough, phlegm yellow sticky.
Formula granule
Usage and dosage with boiled water, 14g each time, 3 times a day; 2 days for a course of treatment.
It is not advisable to drive vehicles and work at heights during medication contraindications.
Adverse reactions
The preparation method is the above nine flavors, except acetaminophen, ampicillin maleate, caffeine, and other honeysuckle and other six flavors of water and boiling twice, * 2 hours, the second 1.5 hours, combined with decoction, filter After that, the filtrate is concentrated to an appropriate amount, and ethanol is added to make the ethanol content 601-65%. Stir well, let stand, filter, and concentrate the filtrate into a thick paste, add acetaminophen, chlorpheniramine maleate, caffeine. The aqueous solution and the sucrose powder and other auxiliary materials are mixed, made into granules, dried, and made into 100 bags of granules or pressed into 100 pieces to obtain.
Specification 14g/bag; 14g/block (including original medicine 25g; containing acetaminophen 168mg)
Pharmacological action
The inspection shall be in accordance with the relevant provisions under the granules (Appendix IC).
Identification (1) Take 20g of this product, grind finely, add 40ml of 0.5% hydrochloric acid ethanol bath, warmly extract for 5 minutes, filter, filter the pH to neutral with ammonia test solution, evaporate and dry, add 5% sulfuric acid solution to the residue. 5 ml was dissolved, filtered, and the filtrate was divided into three portions. Each drop of cesium iodide test solution, potassium iodide test solution, and silicotungstic acid test solution were formed to form a precipitate. (2) Take 20 g of this product, grind finely, add 40 ml of absolute ethanol, dip, filter, and concentrate the filtrate to 10 ml, filter, and use the filtrate as a test solution. Another acetaminophen reference substance, chlorpheniramine maleate reference substance, add absolute ethanol to make a mixed solution containing acetaminophen 17mgl chlorpheniramine maleate 0.3mg per 1ml, as a reference solution . According to the thin layer chromatography (Appendix VIB) test, 4 μl of each of the above two solutions were aspirated and placed on the same silica gel G thin-layer plate, and the methanol-concentrated ammonia test solution (40:0.3) was used as a developing agent to be developed and taken out. Dry and smoke with iodine vapor. In the chromatogram of the test sample, spots of the same color are displayed at positions corresponding to the chromatogram of the reference substance.
The content of the product is taken from 5 bags of the contents or 5 pieces, accurately weighed, finely ground, mixed, accurately weighed the appropriate amount (about equivalent to acetaminophen 0.2g) in a beaker, add ethanol to stir and extract 5 times, Each time 25ml, filtered, the filtrate was combined, placed in a conical flask, evaporated to dryness, add 50ml of dilute hydrochloric acid, heated to reflux for 1 hour, cooled to room temperature, 20ml with water was transferred to the beaker, add potassium bromide 3g, the burette The tip is inserted into the liquid surface at about 2/3, and is titrated rapidly with sodium nitrite titration solution (0.1mol/L). As the drop is stirred, to the near end point, the tip of the burette is raised to the surface, and the tip is washed with a small amount of water. The washing solution is incorporated into the solution, and the titration is continued until a small amount of solution is taken with a thin glass rod and drawn through a blue strip on the white porcelain plate coated with the potassium iodide starch indicating solution. After 1 minute, a little solution is drawn. Once, if the blue streak still appears, it is the end point. Each 1 ml of sodium nitrite titration solution (0.1 mol/L) corresponds to 15.12 mg of C8H9NO2. This product contains acetaminophen (C8H9NO2) per 1g should be 85.0-115.0% of the amount of the standard.
Leachate
Storage seal.
Remarks
Prescription source drug standard - Chinese medicine prescription preparation standard 1997
Standard number WS3-B-2384-97
OTC classification third batch of OTC
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