In a review article published in the British journal Nature on the 27th, the team of scientists at the Japan Institute of Physical Chemistry pointed out that the confusion caused by the random use of cells as "mesenchymal stem cells" (MSC) is being unapproved. The stem cell treatment marketing has helped. Scientists have called for the academic community to urgently need more stringent standards when defining different cell types.
The so-called "mesenchymal stem cells" is a specialized stem cell that has all the commonalities of stem cells, namely self-renewal and multi-directional differentiation. Such cells are currently used most in clinical practice, and in combination with hematopoietic stem cells, can increase the success rate of transplantation and accelerate hematopoietic reconstitution.
However, the scientist of the Institute of Physical and Chemical Research, Douglas Ship and his colleagues, warned in this article that "mesenchymal stem cells" have created an almost magical and per capita impression for the public, and they have become unscrupulous companies to sell to the public. The preferred cell type for approval of treatment. They pointed out: "We must eliminate these misunderstandings."
Every year, there are thousands of research articles on "mesenchymal stem cells." Now, it has been 20 years since the concept of "mesenchymal stem cells" was first proposed, but the voice of questioning its effectiveness has been constant. There is growing evidence that stem cells that are included in "mesenchymal stem cells" eventually become tissue-specific, different types of adult cells.
Xipu and his colleagues called on the world to act together to raise public understanding of the biological characteristics of cells currently classified as "mesenchymal stem cells," such as the standardized analysis of gene expression in each cell. Scientists also call on researchers, regulators, and journal editors to use more precise tags. They stressed: "The scientific community must stop using a general concept to generalize multiple cell types."
The article has been published as a "Nature" review rather than a research paper. The Nature review article is a hot topic on scientific research and its impact, a column written by authoritative experts.
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