Abt-888 Parp Inhibitors Veliparib CAS: 912444-00-9

Veliparib CAS : 912444-00-9
MF:    C13H16N4O.2ClH
MW:    317.218
Chemical Name :(R)-2-(2-methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide

Veliparib (ABT-888) is a potential anti-cancer drug acting as a PARP inhibitor. It kills cancer cells by blocking a protein called PARP, thereby preventing the repair of DNA or genetic damage in cancer cells and possibly making them more susceptible to anticancer treatments. Veliparib may make whole brain radiation treatment work more effectively against brain metastases from NSCLC.

Biological activity
Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM, respectively, and inhibits SIRT2. Phase 3.
In vitro study
ABT-888 effectively inhibited PARP, and the Ki values were 5.2 and 2.9 nM for PARP-1 and PARP-2, respectively. ABT-888 reduced the survival rate of cloned genes in lung cancer H460 cells and inhibited DNA repair. ABT-888 inhibited C41 cells with an EC50 of 2 nM. ABT-888 and radiotracer to reduce tumor angiogenesis.
In vivo studies
ABT-888 delayed tumor growth in NCI-H460 xenograft tumor model. ABT-888 inhibits PARP in the B16F10 and 9L xenograft models, thereby enhancing the anticancer activity of temozolomide. The combination of ABT-888 and Other cytotoxic agents showed potent anti-cancer effects in the MX-1 xenograft model. In the A375 and Colo829 xenograft models, tumor size was increased by 3 and 12.5 mg ABT-888 per kilogram, respectively, and more than 95% of the PAR in the tumor was inhibited.
feature
ABT-888 enhances the effectiveness of common cancer therapies, such as radiotherapy and alkylating agents.


Product name
Veliparib/ABT 888
Synonyms
2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide
CAS No.
912444-00-9
Molecular formula
C13H16N4O
Molecular weight
244.29
Appearance
White powder
Boiling point
579.023°C at 760 mmHg
Assay    
99%
Packing
100mg ; 1g;10g;25g;50g;100g;200g;500g;1Kg
Application
Pharmaceutical Intermediates


Here Guangzhou Quanao chemical Co. Ltd is one of the worlds high-tech enterprise with completely independent intellectual property rights specialized in flavor, steroid powders , semi-finished steroid liquids , Sarm powders  , fragrance, chemical raw material, food additives, cinnamon series, plant extracts, pharmaceutical Products and high-quality powders for sale over several years. We offer you "safety, efficiency, Security" service. Get the service and products Here, we will offer you special discount. Any questions will be welcomed.

Relate Inhibitors products contact Bruce

ABT-888    
AZD2281    
GSK2126458    
BMS777607    
BMS5121458    
VX950    
Telatinib (BAY 57-9352)    
gsk1904529A    
LY2157299    
DMXAA(AS1404,ASA404)    
Brivanib(bms-540215)    
Brivanib alaninate(BMS-582664)    
vx-702    
abt-869    
NPS-2143    
AG014699    
AZD6244    
GSK1070916    
GSK1120212    
A-674563    
MLN8237    
AS605240    
YO01027    
PKI587    
LY2886721    
PF299804    
GSK690693    
PF-04691502    
SRT1720    
PP242    
KW-2478    
YM201636    
ms-275    
PI-103    
PKI-402    
GDC0980    
GSK1292263    
PHA665752    
LY573636    
AZD8055    
KU0063794    
MDV3100    
AST-1306    
Apixaban    
MGCD0103    
XL880    
MGCD265    
sns032    
ABT-263    
ABT-737    
NVP-BGJ398    
BAY73-4506    
Roflumilast,Daxas    
Fasudil hydrochloride    
Pelitinib(EKB-569)    
Neratinib(HKI-272)    
Imatinib    
Erlotinib HCL    
Afatinib(BIBW2992)    
PCI-32765    
AP24534(Ponatinib)    
AT101    
AZD5438    
CX-4945    
LY2109761    
RAF265    
LY294002    
KU55933    
XL184    
Linagliptin    
FUB359    
Canetinib    
Laquinimod    
Mastinib    
Torcetrapib    
Tasosartan    
A-803467    
JTC801    
Pyroxamide    
CP466722    
PF-562771    
TAK285    
ARN-509    
OC000459    
HQL-79    
JTT705    
MK-5108(VX689)    
LY2811376    
ctep    
PF-02341066    
TAK438    
IOX2    
GNF-2    
THIACETAZONE    
PD0325901    
R406    
AT-406    
R547    
CB-7598    
CB7630    
R788    
VU0364439    
TDZD-8    
VU 0361737    
TCS PIM-1 4a    
YS-49    
YM-90K hydrochloride    
PAI-039     
Dapivirine    
WZ 811     
TTP 22     
AG-490    
D-6413    
DY131    
GW 788388    
Merck-5 ,JAK INHIBITOR I     
JAK2 Inhibitor V  Z3    
KU14R     
LDN-211904    
MK 886    
TAC-101     
3-MA    
PHT427    
GW7647    
LY364947    
SB203580    
ZM323881    
ZM306416    
PF8380    
RITA (NSC 652287)    
ACY-1215    
ASP3026    
sch900776    
CP-945598    
OSI-027    
SB431542    
LY2623091    
Tenovin-1     
Apoptosis Activator 2     
HA14-1    
SMI-4a    
TWS119    
VU 0364439    
LY315920    
Anamorelin    
AZD2014    
LY2940680    
LY500307    
LY2608204    
TAK700    
Linagliptin(BI-1356)    
NVP-BHG712    
Amrubicin     
WAY362450    
AZD8931    
  Veliparib CAS : 912444-00-9
MF:    C13H16N4O.2ClH
MW:    317.218
Chemical Name :(R)-2-(2-methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide

Veliparib (ABT-888) is a potential anti-cancer drug acting as a PARP inhibitor. It kills cancer cells by blocking a protein called PARP, thereby preventing the repair of DNA or genetic damage in cancer cells and possibly making them more susceptible to anticancer treatments. Veliparib may make whole brain radiation treatment work more effectively against brain metastases from NSCLC.

Biological activity
Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM, respectively, and inhibits SIRT2. Phase 3.
In vitro study
ABT-888 effectively inhibited PARP, and the Ki values were 5.2 and 2.9 nM for PARP-1 and PARP-2, respectively. ABT-888 reduced the survival rate of cloned genes in lung cancer H460 cells and inhibited DNA repair. ABT-888 inhibited C41 cells with an EC50 of 2 nM. ABT-888 and radiotracer to reduce tumor angiogenesis.
In vivo studies
ABT-888 delayed tumor growth in NCI-H460 xenograft tumor model. ABT-888 inhibits PARP in the B16F10 and 9L xenograft models, thereby enhancing the anticancer activity of temozolomide. The combination of ABT-888 and other cytotoxic agents showed potent anti-cancer effects in the MX-1 xenograft model. In the A375 and Colo829 xenograft models, tumor size was increased by 3 and 12.5 mg ABT-888 per kilogram, respectively, and more than 95% of the PAR in the tumor was inhibited.
feature
ABT-888 enhances the effectiveness of common cancer therapies, such as radiotherapy and alkylating agents.


Product name
Veliparib/ABT 888
Synonyms
2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide
CAS No.
912444-00-9
Molecular formula
C13H16N4O
Molecular weight
244.29
Appearance
White powder
Boiling point
579.023°C at 760 mmHg
Assay    
99%
Packing
100mg ; 1g;10g;25g;50g;100g;200g;500g;1Kg
Application
Pharmaceutical Intermediates


Here Guangzhou Quanao chemical Co. Ltd is one of the worlds high-tech enterprise with completely independent intellectual property rights specialized in flavor, steroid powders , semi-finished steroid liquids , Sarm powders  , fragrance, chemical raw material, food additives, cinnamon series, plant extracts, pharmaceutical Products and high-quality powders for sale over several years. We offer you "safety, efficiency, Security" service. Get the service and products Here, we will offer you special discount. Any questions will be welcomed.

Relate Inhibitors products contact Bruce

ABT-888    
AZD2281    
GSK2126458    
BMS777607    
BMS5121458    
VX950    
Telatinib (BAY 57-9352)    
gsk1904529A    
LY2157299    
DMXAA(AS1404,ASA404)    
Brivanib(bms-540215)    
Brivanib alaninate(BMS-582664)    
vx-702    
abt-869    
NPS-2143    
AG014699    
AZD6244    
GSK1070916    
GSK1120212    
A-674563    
MLN8237    
AS605240    
YO01027    
PKI587    
LY2886721    
PF299804    
GSK690693    
PF-04691502    
SRT1720    
PP242    
KW-2478    
YM201636    
ms-275    
PI-103    
PKI-402    
GDC0980    
GSK1292263    
PHA665752    
LY573636    
AZD8055    
KU0063794    
MDV3100    
AST-1306    
Apixaban    
MGCD0103    
XL880    
MGCD265    
sns032    
ABT-263    
ABT-737    
NVP-BGJ398    
BAY73-4506    
Roflumilast,Daxas    
Fasudil hydrochloride    
Pelitinib(EKB-569)    
Neratinib(HKI-272)    
Imatinib    
Erlotinib HCL    
Afatinib(BIBW2992)    
PCI-32765    
AP24534(Ponatinib)    
AT101    
AZD5438    
CX-4945    
LY2109761    
RAF265    
LY294002    
KU55933    
XL184    
Linagliptin    
FUB359    
Canetinib    
Laquinimod    
Mastinib    
Torcetrapib    
Tasosartan    
A-803467    
JTC801    
Pyroxamide    
CP466722    
PF-562771    
TAK285    
ARN-509    
OC000459    
HQL-79    
JTT705    
MK-5108(VX689)    
LY2811376    
ctep    
PF-02341066    
TAK438    
IOX2    
GNF-2    
THIACETAZONE    
PD0325901    
R406    
AT-406    
R547    
CB-7598    
CB7630    
R788    
VU0364439    
TDZD-8    
VU 0361737    
TCS PIM-1 4a    
YS-49    
YM-90K hydrochloride    
PAI-039     
Dapivirine    
WZ 811     
TTP 22     
AG-490    
D-6413    
DY131    
GW 788388    
Merck-5 ,JAK INHIBITOR I     
JAK2 Inhibitor V  Z3    
KU14R     
LDN-211904    
MK 886    
TAC-101     
3-MA    
PHT427    
GW7647    
LY364947    
SB203580    
ZM323881    
ZM306416    
PF8380    
RITA (NSC 652287)    
ACY-1215    
ASP3026    
sch900776    
CP-945598    
OSI-027    
SB431542    
LY2623091    
Tenovin-1     
Apoptosis Activator 2     
HA14-1    
SMI-4a    
TWS119    
VU 0364439    
LY315920    
Anamorelin    
AZD2014    
LY2940680    
LY500307    
LY2608204    
TAK700    
Linagliptin(BI-1356)    
NVP-BHG712    
Amrubicin     
WAY362450    
AZD8931    
 

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